Vitalism is the belief that the life-principle is essentially immaterial. This originated with Stahl (17th century), and held sway until the middle of the nineteenth century. It appealed to philosophers such as Henri Bergson, Nietzsche, Wilhelm Dilthey, anatomists like Bichat, and chemists like Liebig.

Vitalism underpinned the idea of a fundamental separation of organic and inorganic material, and the belief that organic material can only be derived from living things. This was disproved in 1828 when Wöhler prepared urea from inorganic materials. This so-called Wöhler synthesis is considered the starting point of modern organic chemistry. It is of great historical significance because for the first time an organic compound was produced from inorganic reactants.

Later, Helmholtz, anticipated by Mayer, demonstrated that no energy is lost in muscle movement, suggesting that there were no vital forces necessary to move a muscle. These empirical results led to the abandonment of scientific interest in vitalistic theories, although the belief lingered on in non-scientific theories such as homeopathy, which interprets diseases and sickness as caused by disturbances in a hypothetical vital force or life force.